Plenhyage XL

Injectables Clinic High Wycombe

Plenhyage XL Treatment

Plenhyage XL is a new generation, regenerating injectable skin treatment which is designed to rejuvenate skin and improve lines and wrinkles. It stimulates the skin to produce new collagen and elastin resulting in improved thickness and hydration of the skin.

Plenhyage XL is based on PDRN (Polydeoxyribonucleotide) that comes from salmon. It works by stimulating specific cells in the skin called fibroblasts. Fibroblasts make new collagen and other matrix macromolecules which lay the foundation of new skin.

The application of Plenhyage XL is highly versatile in aesthetics. It can be used in the treatment of fine lines, wrinkles, pigmentation, and scars. It has an overall positive effect on all signs of skin ageing.

Plenhyage XL

What our Clients say

For many people, especially if you are contemplating cosmetic treatment for the first time, or if you are unsure a particular treatment is for you, hearing feedback from our many delighted clients can be reassuring and helpful. 

Amanda Walters
Amanda Walters
I went to Javaani for a HIFU face lift treatment. My experience was wonderful. The staff are really attentive and kind. The level of care here is top. I definitely recommend.
bhavanpreet johal
bhavanpreet johal
I visited the clinic for the first time after a friend's recommendation to receive a hydra facial before my big day. Anu provided outstanding service and is incredibly friendly and bright. My skin has never felt better, and the treatment was carried out with care and patience. Undoubtedly, I'll return.
I had a hydrafacial at the Javaani Clinic for the second time. Really excellent service and treatment! Anu, who performed my treatment, was incredibly knowledgeable and kind. In addition to thoroughly explaining each step of the procedure, she also gathered information about my previous skin care regimen to tailor the treatment. My skin is glowing within. Looking forward to returning!
Anna Szurgut
Anna Szurgut
I am very satisfied with the Javaani Aesthetic Clinic. This is a different experience to what I have had before elsewhere. I was very pleased to experience this professional, educational, gentle approach from Javaani’s practitioners. Before that, my experience with hair mesotherapy was very unpleasant and painful. At Javaani, it was proved to me that it can be a really enjoyable experience. Thank you. I'm coming back to finish the course.
Reema Mahay
Reema Mahay
My experience at Javaani Aesthetics has been phenomenal. The staff are welcoming, approachable and friendly which has left me feeling comfortable every time I have visited. I have had two sessions of PRP for hair loss, Dr Ahmed has conducted the procedures and regularly checked with me to ensure the procedure was comfortable. I also appreciated the information and aftercare guidance. I would highly recommend this Clinic.
Ana Martinez
Ana Martinez
I've had radio frequency and ultrasonic cavitation on my belly as I've lost some weight but my belly(mum belly) above my c section scar has been an issue. I'm so far amazed by the results- 3 more sessions to go. Thanks Shakeela for trying to give me a nice waistline!
Saida Bougrine
Saida Bougrine
I had Hifu treatment done by Anu I am very pleased with the results, Anu explained everything throughout the consultation and made me comfortable during the treatment I highly recommend javaani aesthetic clinic .
Olivia W
Olivia W
I had my first ever skinpen treatment here and loved it. Very comfortable and relaxing experience for me and lovely staff too. Thank you
Excellent treatments and fantastic customer service, each member of staff is professionally trained to the highest level, they make you feel young and youthful, highly recommend to everyone
Bushra Khanum
Bushra Khanum
Truthfully the best facial experience I’ve ever had. Therapist, Shakeela was very efficient, friendly and professional. Highly recommend. Will definitely be back!

Treatment Summary


Procedure Time

30 Mins

Back to Work


Duration of Results

up to 9 Months

Pain Level

Mild with numbing cream

Plenhyage XL FAQS


What are the effects of Plenhyage XL at cellular level?

1. New cell production
2. Formation of new collagen and elastin
3. Production of Hyaluronic Acid
4. Stimulates formation of new micro blood vessels (Angiogenesis)
5. Suppression of pigmentary cells (melanin)
6. Anti-Inflammatory effect on the skin
7. Stimulates Fibroblast activity

What areas on the body and face can you use Plenhyage XL?

Plenhyage XL is available in two different strengths for different parts of the body.

In addition to treatments for the upper, mid and lower face, Plenhyage XL can also be used to treat the neck, décolletage, inner arms, thighs, and knees. It will also be particularly useful for difficult areas such as the neck and beneath the eyes.

Plenhyage XL is available in two doses.

1. Medium
For facial lines, wrinkles, and loose skin
For dark under-eye circles

2. Strong
For wrinkles and creases of the neck and decollate area
For acne scars
For treating other body areas hands, knees and elbows

How is Plenhyage XL different from filler?

Dermal fillers simply add volume to the skin.

Plenhyage XL does not add volume instead it regenerates the area where it is injected.

How is Plenhyage XL different from a skin booster?

A Skin booster is usually made of hyaluronic acid and amino acids. They hydrate, give nutrition to the skin and have some volumisation effect. The results only last a few months.
Plenhyage XL is purified PDRN which regenerates the skin. This stimulates fibroblast which produces new collagen, reduces inflammation, regulates skin pigmentation, and improves hydration and skin tone.

When are the results visible?

Results develop over the following 3 to 4 weeks and additional treatments can be done every 3-4 weeks.

How long do Plenhyage XL results last?

Results last from 6 to 9 months

Gini P

Jan 27, 2023

Amazing experience as always.

Very friendly and professional staff/doctor.


Swathi A

Jan 27, 2023

It has been a great experience for me. Anu has taken lovely care and I recommend Javaani clinic to my friends.



Dec 10, 2022

The treatment was fantastic! Very professional and friendly. I would recommend this place to anyone!

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