Plenhyage XL

Injectables Clinic High Wycombe

Plenhyage XL Treatment

Plenhyage XL is a new generation, regenerating injectable skin treatment which is designed to rejuvenate skin and improve lines and wrinkles. It stimulates the skin to produce new collagen and elastin resulting in improved thickness and hydration of the skin.

Plenhyage XL is based on PDRN (Polydeoxyribonucleotide) that comes from salmon. It works by stimulating specific cells in the skin called fibroblasts. Fibroblasts make new collagen and other matrix macromolecules which lay the foundation of new skin.

The application of Plenhyage XL is highly versatile in aesthetics. It can be used in the treatment of fine lines, wrinkles, pigmentation, and scars. It has an overall positive effect on all signs of skin ageing.

Plenhyage XL

What our Clients say

For many people, especially if you are contemplating cosmetic treatment for the first time, or if you are unsure a particular treatment is for you, hearing feedback from our many delighted clients can be reassuring and helpful. 

Shakeela BannoShakeela Banno
10:10 15 Jul 23
Very welcoming and always listening to my needs. Shakeela always is polite and courteous and takes her time to ensure the most effective treatment. I have noticed my hair reduce in quantity and thickness following my laser and IPL session on face, underarms and bikini. Recommend always as always professional
Milena CerovaMilena Cerova
12:48 24 Jun 23
Very pleasure experience with Shakeela today.She is amazing!
Shaheen BibiShaheen Bibi
22:02 05 May 23
Dr. Ahmad is very thorough and professional and explained very kindly about the treatment. All the staff are very friendly, helpful and kind. I had a wonderful experience and felt very welcome. I would definitely recommend Javaani Clinic to anyone.
Femy AminFemy Amin
19:34 29 Apr 23
I had a great experience at the clinic. Anu was very helpful initially in booking me in - very responsive and easy to book. During my visit I met Shakila, who was just as lovely with a warm and friendly approach. I had my consultation with Dr. Ahmed, who was patient in providing me with all the necessary information and treatment options that best suited my needs. I went ahead with microneedling and was very happy with the care and attention to detail. It's only been a day so waiting to see the outcome but skin healing well and I'm satisfied so far!
Andy HAndy H
13:46 24 Apr 23
Great experience at Javaani. All the staff are very welcoming and friendly, the treatment received by Shakeela was very professional. Highly recommended.
marta kalimarta kali
15:28 24 Feb 23
Shakeela was amazing today, very patient and professional. She explained the procedure and aftercare really well. Place was exceptionally clean. I would definitely come back for more treatments in the future.

Treatment Summary


Procedure Time

30 Mins

Back to Work


Duration of Results

up to 9 Months

Pain Level

Mild with numbing cream

Plenhyage XL FAQS


What are the effects of Plenhyage XL at cellular level?

1. New cell production
2. Formation of new collagen and elastin
3. Production of Hyaluronic Acid
4. Stimulates formation of new micro blood vessels (Angiogenesis)
5. Suppression of pigmentary cells (melanin)
6. Anti-Inflammatory effect on the skin
7. Stimulates Fibroblast activity

What areas on the body and face can you use Plenhyage XL?

Plenhyage XL is available in two different strengths for different parts of the body.

In addition to treatments for the upper, mid and lower face, Plenhyage XL can also be used to treat the neck, décolletage, inner arms, thighs, and knees. It will also be particularly useful for difficult areas such as the neck and beneath the eyes.

Plenhyage XL is available in two doses.

1. Medium
For facial lines, wrinkles, and loose skin
For dark under-eye circles

2. Strong
For wrinkles and creases of the neck and decollate area
For acne scars
For treating other body areas hands, knees and elbows

How is Plenhyage XL different from filler?

Dermal fillers simply add volume to the skin.

Plenhyage XL does not add volume instead it regenerates the area where it is injected.

How is Plenhyage XL different from a skin booster?

A Skin booster is usually made of hyaluronic acid and amino acids. They hydrate, give nutrition to the skin and have some volumisation effect. The results only last a few months.
Plenhyage XL is purified PDRN which regenerates the skin. This stimulates fibroblast which produces new collagen, reduces inflammation, regulates skin pigmentation, and improves hydration and skin tone.

When are the results visible?

Results develop over the following 3 to 4 weeks and additional treatments can be done every 3-4 weeks.

How long do Plenhyage XL results last?

Results last from 6 to 9 months

Gini P

Jan 27, 2023

Amazing experience as always.

Very friendly and professional staff/doctor.


Swathi A

Jan 27, 2023

It has been a great experience for me. Anu has taken lovely care and I recommend Javaani clinic to my friends.



Dec 10, 2022

The treatment was fantastic! Very professional and friendly. I would recommend this place to anyone!

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